Personalized Immunotherapy Strategies
Innovative approaches to monitoring and managing cytokine release syndrome in hematologic patients undergoing hematopoietic stem cell transplantation (HSCT), chimeric antigen receptor T-cell (CAR-T) therapy, and bispecific antibodies (BsAbs): discovery and validation of novel biomarkers and personalized strategies.
Early Detection of KSHV-Associated Inflammatory Cytokine Syndrome and KSHV-related tumors Serologic screening and molecular surveillance of Kaposi sarcoma herpesvirus (KSHV/HHV-8) infections; analysis of T-cell responses to latent and lytic antigens; assessment of v-miRNA profiles across HHV-8 related diseases and evaluation of clonal hematopoiesis in transplant recipients, aimed at early recognition and effective treatment of KSHV-associated inflammatory cytokine syndrome and KSHV related neoplasias (Kaposi sarcoma and lymphoproliferative diseases) in solid organ transplant patients.